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TransCode Therapeutics, Inc. is a clinical-stage oncology company focused on treating metastatic disease. It is focused on defeating cancer through the intelligent design and effective delivery of RNA therapeutics based on its proprietary TTX nanoparticle platform. Its lead therapeutic candidate, TTX-MC138, is focused on treating metastatic tumors which overexpress microRNA-10b, a well-documented biomarker of metastasis. It is also developing a portfolio of other RNA therapeutic candidates designed to overcome the challenges of RNA delivery and thus unlock therapeutic access to a variety of novel genetic targets that could be relevant to treating a variety of cancers. Its preclinical programs include TTX-siPDL1, is an siRNA-based modulator of programmed death-ligand 1, or PD-L1, TTX-RIGA, is an RNA-based agonist of the retinoic acid-inducible gene I, or RIG-I, targeting activation of innate immunity in the tumor microenvironment and TTX-siMYC is a siRNA-based inhibitor of c-MYC.
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