| 15 October 2026 | Elizabeth BhattPresident/COO | Sell Option/Award related | 1,094 | $36.87 | $40,337.42 | 177,115 |
| 15 October 2026 | Elizabeth BhattPresident/COO | Sell Option/Award related | 2,906 | $37.61 | $109,306.87 | 174,209 |
| 1 September 2026 | Daniel D (Dan) LongSenior Vice President | Sell Option/Award related | 3,333 | $37.83 | $126,077.72 | 96,412 |
| 12 August 2026 | THIRD ROCK VENTURES V LPVenture Capital | Sell Regular sell transaction (market) | 147,059 | $50.27 | $7,392,655.93 | 6,068,532 |
| 12 August 2026 | THIRD ROCK VENTURES V LPVenture Capital | Sell Regular sell transaction (market) | 141 | $51.08 | $7,202.28 | 6,068,391 |
| 12 August 2026 | RA CAPITAL MANAGEMENT LPInvestment Management Company | Sell Regular sell transaction (market) | 746,500 | $42.50 | $31,726,250.00 | 4,777,415 |
| 12 August 2026 | RA CAPITAL MANAGEMENT LPInvestment Management Company | Sell Regular sell transaction (market) | 746,500 | $42.50 | $31,726,250.00 | 725,443 |
| 11 August 2026 | Elizabeth BhattPresident/COO | Sell Option/Award related | 25,000 | $44.00 | $1,100,000.00 | 174,209 |
| 3 August 2026 | Daniel D (Dan) LongSenior Vice President | Sell Option/Award related | 1,000 | $33.98 | $33,975.60 | 98,746 |
| 3 August 2026 | Daniel D (Dan) LongSenior Vice President | Sell Option/Award related | 2,334 | $34.68 | $80,944.29 | 96,412 |