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AstraZeneca (Q2 Results): trading and guidance in-line

The second quarter has been another period of solid financial and clinical delivery for AstraZeneca.
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AstraZeneca’s second-quarter revenue was in line with forecasts at $15.4bn, up 5% when ignoring exchange rate impacts. Oncology, Respiratory and Rare Disease more than offset weakness elsewhere in the therapeutic mix.

Core operating profit rose 10% to $5.2bn, with margins up two percentage points to 34%, as revenue growth and improved product profitability more than offset rising Research & Development and other costs.

Free cash flow in the first half declined 18% to $4.9bn, as a higher share of profit was absorbed by day-to-day operating cash movements and higher tax payments. Net debt increased from $25.3bn to $26.9bn.

AstraZeneca reiterated full-year guidance for mid-to-high single-digit revenue growth and low double-digit growth in core earnings per share.

The shares were up 1.2% in early trading.

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AstraZeneca key facts

All ratios are sourced from LSEG Datastream, based on previous day’s closing values. Please remember yields are variable and not a reliable indicator of future income. Keep in mind key figures shouldn’t be looked at on their own – it’s important to understand the big picture.

This article is original Hargreaves Lansdown content, published by Hargreaves Lansdown. It was correct as at the date of publication, and our views may have changed since then. Unless otherwise stated estimates, including prospective yields, are a consensus of analyst forecasts provided by LSEG. These estimates are not a reliable indicator of future performance. Yields are variable and not guaranteed. Investments rise and fall in value so investors could make a loss.

This article is not advice or a recommendation to buy, sell or hold any investment. No view is given on the present or future value or price of any investment, and investors should form their own view on any proposed investment.

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Written by
Derren Nathan
Derren Nathan
Head of Equity Research

Derren leads our Equity Research team with more than 15 years of experience in his field. Thriving in a passionate environment, Derren finds motivation in intellectual challenges and exploring diverse ideas within his writing.

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Article history
Published: 27th July 2026