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GSK (Q3 Results): guidance upgraded

Outgoing CEO Dame Emma Walmsley has delivered her final set of results, delivering both a beat on forecasts and a full-year upgrade.
Female scientist using a microscope in a lab for drug development.jpg

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GSK’s third quarter revenue grew 8% to £8.5bn (£8.2bn expected) when ignoring currency moves. All segments and regions were up, with speciality medicines and Europe leading the growth.

Underlying operating profit rose 11% to £3.0bn, helped by a shift in the sales mix towards higher margin products.

Free cash flow fell by £0.1bn to £1.2bn, reflecting a higher level of capital expenditure. Net debt of £14.4bn is up £1.4bn year to date driven by acquisitions and shareholder payouts.

GSK declared a quarterly dividend of 16p, with a total of 64p still expected for the year.

Full year sales growth guidance has been upgraded from around 5% to 6-7%, and underlying operating profit guidance has been upped from 8% to 9-11% growth.

The shares rose 4.2% in early trading.

Our view

Investors lapped up Emma Walmsley’s curtain call as she signed off on her final set of results with a healthy upgrade to full year guidance, reinforcing our view that incoming CEO Luke Miels has a strong platform to build on.

With 15 major pipeline launches planned by 2031 we think GSK’s prospects are strong, with plenty of pipeline milestones anticipated for next year. In the more immediate future, headwinds for US vaccine sales are being offset by strong growth in the category overseas.

Elsewhere, the group also has a strong presence in HIV treatments which make up about 20% of total revenues. Its newer HIV treatments are a key part of the story, and they’re seeing some impressive growth. A strong clinical pipeline of next-generation HIV therapies should further help bolster GSK’s market position.

Respiratory disease is another key therapeutic focus. Here, GSK has its sights set on improving outcomes for sufferers of COPD, the third leading cause of death worldwide. Meanwhile, Cancer treatment, although relatively small in terms of current sales, is growing rapidly. Recent approvals and launches in new markets mean there are strong growth drivers for the existing portfolio. The development pipeline looks promising.

Net debt has been coming down and currently sits at about 1.4x forecast cash profits, which we don't see as a major concern. Improving underlying cash generation helps support a prospective dividend yield of 4.2% and share buybacks, but remember, no payouts to shareholders can be assured.

Investor sentiment toward the pharmaceutical industry has been damaged this year by rapidly changing and unclear policy in the United States. The most recent twist saw the US slap a 100% levy on imported branded medicines, with the exception of companies building manufacturing facilities in America. We think GSK’s substantial stateside investment commitments should shield investors from this threat.

Pressure on drug pricing looks to be the bigger policy risk, but there are plenty of obstacles to clear if Donald Trump’s proposals are to become law. But the continuing uncertainty means volatility could be higher than usual.

The valuation is significantly less demanding than many of its peers, reflecting relatively modest forecasts and perceptions around its ability to commercialise its research efforts. We see some upside potential if GSK continues to close in on its longer-term ambition. The CEO designate has a promising set of products and pipeline assets to help him on his way, but given the risks involved in drug discovery, there can be no guarantee.

Environmental, social and governance (ESG) risk

The pharmaceuticals sector is relatively high-risk in terms of ESG. Product governance, particularly with safety and marketing, and affordable access to treatment are the key risk drivers. Labour relations, business ethics and bribery and corruption are also contributors to ESG risk.

According to Sustainalytics, GSK's overall management of material ESG issues is strong.

There's an independent, board-level, corporate responsibility committee focused on ESG performance and framework and 10% of executive pay is tied to ESG metrics. It's ranked first on both the Access to Medicine Index and Access to Vaccines Index thanks to industry-leading efforts to ensure medicines and vaccines are provided to patients in need. Management practices concerning the transparency of clinical trials are strong, and it's committed to international standards. But despite a strong product safety programme, GSK lacks external quality management certification at its manufacturing sites.

Parties related to the author hold shares in GSK.

GSK key facts

All ratios are sourced from LSEG Datastream, based on previous day’s closing values. Please remember yields are variable and not a reliable indicator of future income. Keep in mind key figures shouldn’t be looked at on their own – it’s important to understand the big picture.

This article is original Hargreaves Lansdown content, published by Hargreaves Lansdown. It was correct as at the date of publication, and our views may have changed since then. Unless otherwise stated estimates, including prospective yields, are a consensus of analyst forecasts provided by LSEG. These estimates are not a reliable indicator of future performance. Yields are variable and not guaranteed. Investments rise and fall in value so investors could make a loss.

This article is not advice or a recommendation to buy, sell or hold any investment. No view is given on the present or future value or price of any investment, and investors should form their own view on any proposed investment.

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Written by
Derren Nathan
Derren Nathan
Head of Equity Research

Derren leads our Equity Research team with more than 15 years of experience in his field. Thriving in a passionate environment, Derren finds motivation in intellectual challenges and exploring diverse ideas within his writing.

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Article history
Published: 29th October 2025